About duetact

Duetact and blood sugar (glucose)

The main goal of type 2 diabetes treatment is to keep your blood sugar level within a target range. The American Diabetes Association recommends the following blood sugar goals for people with diabetes:

  • Before meals: Your premeal blood glucose should be between 90 mg/dL and 130 mg/dL.
  • After meals: Your highest postmeal (1 to 2 hours after eating) blood glucose should be less than 180 mg/dL.
  • Your average blood sugar for the last 2–3 months (A1C): Your A1C should be less than 7%.

Reasons for high blood sugar levels

Healthy eating and physical activity are always essential to help meet these goals, but despite your best efforts, your blood sugar could end up out of control due to one or more of the following factors:

  • Stress or illness.
  • Change in diet.
  • Limited physical activity.
  • Need for medication or adjustment of medication.
  • Forgetting to take diabetes medication as prescribed.
  • The natural progression of type 2 diabetes.

People with type 2 diabetes still produce insulin. However, two things can happen:
1. their body doesn’t respond to insulin’s action (it’s resistant), or
2. there isn’t enough insulin being produced.

Duetact contains two medications in one tablet that, along with healthy eating and physical activity, work together to help lower your blood sugar. The ACTOS component of duetact works by decreasing insulin resistance. And the glimepiride component works mainly by stimulating the pancreas to release more insulin.

Next: Duetact, cholesterol, and blood fats (triglycerides)

Management of type 2 diabetes should also include nutritional counseling, weight reduction as needed, and exercise.

Please see Important Safety Information, including warning about heart failure, below.

Important Safety Information About duetact® (pioglitazone HCl and glimepiride)

Duetact contains 2 prescription antidiabetic medicines: pioglitazone HCl (ACTOS) and glimepiride, a sulfonylurea. Duetact is used with diet and exercise to improve blood sugar (glucose) control in adults with type 2 diabetes who are already taking ACTOS and a sulfonylurea together, or taking a sulfonylurea alone and it is not controlling blood sugar.

Duetact is not for everyone. Certain patients with heart failure should not start taking duetact. Duetact can cause or worsen congestive heart failure. Talk to your doctor immediately if you experience rapid weight gain, fluid retention (swelling), or shortness of breath.

Do not take duetact if you have active liver disease. Your doctor should perform a blood test to check for liver problems before you start duetact and periodically thereafter. Talk to your doctor immediately if you experience nausea, vomiting, stomach pain, tiredness, loss of appetite, dark urine, or yellowing of the skin. Some people taking duetact may experience flu-like symptoms, mild-to-moderate swelling of legs and ankles, and anemia. Duetact may cause low blood sugar. Lightheadedness, dizziness, shakiness, or hunger may mean that your blood sugar is too low. Talk to your doctor if low blood sugar is a problem for you.

Duetact may increase your risk of becoming pregnant. If you are pregnant or thinking about becoming pregnant, talk to your doctor before taking duetact. If you are nursing, do not take duetact. Some people, particularly women, are at higher risk of having bone fractures while taking duetact. Patients with diabetes should have regular eye exams. If you experience vision problems, consult your doctor immediately. Very rarely, some patients have experienced visual changes while taking pioglitazone, a component of duetact. Duetact should not be used in patients with type 1 diabetes.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch, or call 1-800-FDA-1088.